解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Nasopharyngeal carcinoma (NPC) has been shown to be highly responsive to chemotherapy. The major limiting toxicity was myelotoxicity. Recently, the role of granulocyte colony-stimulating factor (G-CSF) in reducing chemotherapy-induced neutropenic sepsis has been well established. In this study, we tested whether recom...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227658
更新日期:1997-01-01 00:00:00
abstract::In patients affected with different tumours, disorders concerning clotting are frequently observed. The biological processes leading to coagulation are probably involved in the mechanisms of metastasis. We studied plasma levels of thrombin-antithrombin III complexes (TAT) in 90 patients affected with lung tumours subg...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227620
更新日期:1996-11-01 00:00:00
abstract::Thrombopoietin (TPO) is a recently discovered hematopoietic growth factor which stimulates the production and maturation of megakaryocytes. In this study, we used a modified MTT assay to examine the in vitro growth-stimulatory effects of recombinant human (rh) TPO and recombinant human stem cell factor (rhSCF) on eigh...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227600
更新日期:1996-09-01 00:00:00
abstract::The role of p53, retinoblastoma (RB) and c-erbB-2 gene proteins in the pathogenesis of anal carcinomas has been examined. A total of 97 patients were included in the study. c-erbB-2, RB and p53 proteins were abnormal in 0, 5 and 34% of the cases, respectively. No correlation was observed between p53 and age, sex, tumo...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227590
更新日期:1996-09-01 00:00:00
abstract::Retinoids are differentiating agents that have been used successfully for the treatment of acute promyelocytic leukemia. When combined with interferons, they are active in preventing second malignancies in patients with head and neck cancer. Our previous studies have demonstrated cytostatic effects of alltrans-retinoi...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227583
更新日期:1996-07-01 00:00:00
abstract::The levels of bone-specific alkaline phosphatase (BALP) in plasma and tumour tissue samples of 20 Chinese patients with osteosarcoma in Hong Kong were measured by the wheat germ lectin precipitation technique. The plasma BALP levels in these patients were significantly higher than those of the normal subjects (p < 0.0...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227573
更新日期:1996-07-01 00:00:00
abstract::The methodology of future antiemetic studies will reflect the need to address the problems identified in current studies. New preclinical information on the mechanisms of emesis and antiemetic action will allow more rational clinical study design. Prior to large randomized studies, phase I and II trials should define ...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000227648
更新日期:1996-06-01 00:00:00
abstract::Anticipatory nausea and vomiting (ANV) are learned responses to chemotherapy that develop in up to 25% of patients by the fourth treatment cycle. Post-treatment nausea and emesis must occur before development of ANV can take place. Certain patient characteristics and other responses to chemotherapy can also be used to...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000227633
更新日期:1996-06-01 00:00:00
abstract::To improve the ability of an in vitro drug sensitivity test to predict in vivo effects, we applied a drug concentration that was pharmacokinetically equivalent to plasma levels and collagen gel droplet-embedded culture with a high cloning efficiency. We reported that the cell-killing effect of cell cycle phase-nonspec...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227569
更新日期:1996-05-01 00:00:00
abstract::An immunohistochemical stain to the c-ErbB-2 protein was performed in 225 paraffin-embedded tissue blocks from patients with locally advanced gastric cancer who underwent curative resection. The overexpression of the c-ErbB-2 protein was observed in 27.4% of the patients. The c-ErbB-2 positivity showed a statistically...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227559
更新日期:1996-05-01 00:00:00
abstract::362 evaluable node-positive patients with stage II breast cancer were randomized, receiving either 6 cycles of conventional CMF or 6 cycles of the combination of cyclophosphamide (500 mg/m2), mitoxantrone (Novantrone 10 mg/m2), and fluorouracil (500 mg/m2; CNF). After a median follow-up of 51 months, 64 (36%) patients...
journal_title:Oncology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000227550
更新日期:1996-03-01 00:00:00
abstract::The prognosis of brain glioblastoma is still very poor and the median survival time is generally less than 6 months. At present, no chemotherapy has appeared to influence its prognosis. On the other hand, recent advances in brain tumor biology have suggested that brain tumor growth is at least in part under a neuroend...
journal_title:Oncology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000227533
更新日期:1996-01-01 00:00:00
abstract::Hemostatic abnormalities are rather frequent in cancer patients either in hematological or in solid tumors. Acute disseminated intravascular coagulation (DIC) is a rare coagulopathy in cancer patients, but when it develops it becomes rapidly fatal. Between June 1988 and December 1992 we observed 8 cases of acute DIC o...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227520
更新日期:1995-11-01 00:00:00
abstract::In order to assess the feasibility of a sequential hormonal treatment after tamoxifen failure, 24 postmenopausal advanced breast cancer patients (median age 60 years; ECOG PS < or = 1) were treated with formestane (4-hydroxyandrostenedione) 250 mg i.m. fortnightly; 19 patients were estrogen receptor-positive. The site...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000227510
更新日期:1995-11-01 00:00:00
abstract::We examined the effects of cycloheximide on the amount of chromatin-bound and -unbound PCNA subpopulations in HeLa cells. The chromatin-bound PCNA content decreased rapidly in the presence of cycloheximide, whereas the reduction of the total amount of PCNA was minimal even 24 h after the treatment with cycloheximide. ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227500
更新日期:1995-09-01 00:00:00
abstract::38 of 306 patients survived beyond 5 years after resection of an exocrine pancreatic carcinoma during a period from 1971 to 1993. Amongst the long-term survivors there were 12 patients with ductal, 22 with ampullary, 3 with distal bile duct and 1 with duodenal cancer. An active operative strategy was employed in order...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227488
更新日期:1995-09-01 00:00:00
abstract::To establish appropriate indications for endoscopic treatment of submucosal invasive gastric carcinoma, we investigated clinicopathologic features and proliferating cell nuclear antigen (PCNA) expression at the deepest invasive portion of 192 differentiated submucosal invasive gastric carcinomas that had been surgical...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227486
更新日期:1995-07-01 00:00:00
abstract::We report four cases of Hodgkin's disease (HD) relapsing after complete remission for over a 10-year period after the initial therapy. Three of the patients had mixed-cellularity subtypes as a primary histological diagnosis, and the rebiopsies demonstrated mixed cellularity in all very late relapse cases. Two patients...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227474
更新日期:1995-07-01 00:00:00
abstract::From January 1991 to August 1993, 237 women with metastatic breast cancer were recruited into a multicentric phase II clinical trial designed to assess the cardioprotective activity of Cardioxane (ICRF-187). All patients were treated with 5-fluorouracil 500 mg/m2, doxorubicin 50 mg/m2, cyclophosphamide 500 mg/m2 (FDC)...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000227467
更新日期:1995-05-01 00:00:00
abstract::Breast conservation treatment followed, if useful, by adjuvant therapy is the treatment of choice in early breast cancer. Late cosmetic outcome and toxicity are important in comparing conservative treatment to mastectomy. We reviewed the records of 225 patients treated from 1981 to 1988 with a median follow-up of 74 m...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227454
更新日期:1995-05-01 00:00:00
abstract::Several reports have demonstrated an adverse effect of perioperative blood transfusions on the survival of patients with various solid tumors treated surgically. We retrospectively investigated the relationship between perioperative blood transfusions and the survival of 501 patients who underwent radical subtotal gas...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227452
更新日期:1995-03-01 00:00:00
abstract::Thirteen samples of gastric tumors that had developed in the remnant stomach (remnant gastric cancer) were compared with 63 samples of primary gastric tumors located in the upper third of the stomach (primary gastric cancer) by both clinicopathologic and flow cytometric analysis. The depths of invasion of all these tu...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227441
更新日期:1995-03-01 00:00:00
abstract::Sixteen patients with histologically confirmed inoperable hepatocellular carcinoma were treated with vindesine 3 mg/m2 i.v. weekly. Anemia, leukopenia and neuritis were documented but no severe or life-threatening toxicity was seen. There were no objective responses among the 14 evaluable patients. Eight had a no chan...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000227434
更新日期:1995-01-01 00:00:00
abstract::In 323 of 1,620 patients with gastric cancer, the lesion was > or = 10 cm in maximum diameter. Studies were done with respect to clinicopathologic features and the prognosis. Patients with tumors > or = 10 cm were younger and women patients were more numerous compared to those with tumors < 10 cm. Tumors were more adv...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227424
更新日期:1995-01-01 00:00:00
abstract::The activities of established and experimental antitumor drugs were tested against the BRO and MeWo human melanomas transplanted in the subrenal capsule of phenotypically immunocompetent (CBA x C57BL/6)F1 mice. Immunosuppression was achieved with preliminary whole-body radiation, and cytological examination showed tha...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227400
更新日期:1994-11-01 00:00:00
abstract::Flow cytometric (FCM) DNA studies were performed on cell suspensions obtained by endoscopic biopsy in 73 patients with gastric cancer and in 61 patients with gastric remnant. In cancer, DNA aneuploidies were detected in 49 tumors (67.1%), including 51.7% (15/29) of early gastric cancers and 77.3% (34/44) of advanced g...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227389
更新日期:1994-11-01 00:00:00
abstract::We report a rare case of a patient with an intrasplenic malignant fibrous histiocytoma (MFH) and chronic myelogenous leukemia. The neoplasms were synchronous in their onset and evolution. The peculiarity of the primary site of the MFH, the genetic implications of multiple primary tumors in a single patient, and the co...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227384
更新日期:1994-09-01 00:00:00
abstract::We investigated the effects of piroxicam, a cyclooxygenase inhibitor, and esculetin, a lipoxygenase inhibitor, on 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary carcinogenesis in female rats. Seven days after receiving a 5-mg dose of DMBA, rats were fed either a high-fat (20% soybean oil) or low-fat (0.5% soybe...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227374
更新日期:1994-09-01 00:00:00
abstract::Twenty-two patients with metastatic breast carcinoma were treated with a combination of cisplatin (100 mg/m2 i.v. day 1) and etoposide (100 mg/m2 i.v. days 1-3). Eligible patients had measurable disease with normal organ functions, performance status < 3, age < 70 years and no previous chemotherapy for metastatic dise...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000227364
更新日期:1994-07-01 00:00:00
abstract::The paper presents the experience with watch-and-wait policy following radical surgery in 25 patients with primary gastric non-Hodgkin's (NH) lymphoma localized to the gastric wall. The median follow-up is at the moment 40 months (range 18-85). Only 3/25 patients have relapsed (during the first year of the follow-up) ...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000227347
更新日期:1994-05-01 00:00:00
abstract::This paper reviews the effectiveness of local interleukin-2 (IL-2) therapy and its effector induction mechanisms in vivo. Local therapy with IL-2 and/or lymphokine-activated killer (LAK) cells is associated with far fewer side effects than systemic treatment. Local infusions of IL-2 into malignant pleural effusions an...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000227331
更新日期:1994-03-01 00:00:00
abstract::Recombinant human granulocyte colony-stimulating factor (G-CSF) has been used worldwide in cancer patients for over 1 year, and (only 5 years from the first publication on the clinical use of this growth factor) experience is rapidly accumulating in many oncological situations. Several randomized studies have confirme...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000227333
更新日期:1994-03-01 00:00:00
abstract::A multidrug-resistant (MDR) cell line isolated from HOB1 lymphoma cells was characterized. The MDR phenotype in this cell line was typified by resistance to vincristine with varying degrees of cross-resistance to Adriamycin, colcemid and actinomycin D. Decreased intracellular [3H]vincristine with concurrent increase i...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227300
更新日期:1994-01-01 00:00:00
abstract::Twelve patients with advanced primary lung cancers associated with malignant pleural effusion were treated with intrathoracic instillation of recombinant interleukin-2 with or without in-vitro-sensitized cells. Two cases achieved complete response, and 7 partial response. The adverse effects seen in the protocol were ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227317
更新日期:1994-01-01 00:00:00
abstract::Of 352 patients with colorectal carcinoma followed for a minimum of 5 years after surgery, 39 cases (11.1%; median age 60 years) had mucinous adenocarcinoma, and 4 (1.1%; median age 62 years) had signet-ring cell carcinoma. Mucinous carcinomas were most frequently located in the rectum (61.5%) and in the sigmoid colon...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227306
更新日期:1994-01-01 00:00:00
abstract::Cisplatin is among the most active agents available for the therapy of non-small cell lung cancer (NSCLC). Its congener, carboplatin, has been the focus of intense clinical trials over the last several years because of its improved therapeutic index. Results from randomized trials have shown that carboplatin is active...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000227259
更新日期:1993-11-01 00:00:00
abstract::The purpose of this study was to evaluate in a dog model whether intrapericardial instillation of tetracycline is superior to the effect of drainage alone in causing pericardial adhesions and cavity obliteration. Twelve mongrel dogs were randomly divided into two experimental groups. All dogs received a pericardial dr...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227232
更新日期:1993-11-01 00:00:00
abstract::There are numerous data on the immunostimulative and antitumorous activity of various Viscum album tissue extracts. Isorel (Novipharm, Austria) is one of these compounds. We found that in mice an increased number of plaque-forming cells to sheep red blood cells (SRBC) followed the injection of Isorel together with SRB...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227217
更新日期:1993-11-01 00:00:00
abstract::The authors have reviewed the medical records of 421 sessions of hyperthermia treatments in 73 patients treated between 1987 and 1992 at the University Heights Cancer Center and the Indiana University Medical Center in Indianapolis, Ind. Temperatures attained during the course of therapy on each patient have been aver...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000227209
更新日期:1993-09-01 00:00:00
abstract::Since aspirin was found to cause a persistent decrease in pyruvate kinase activity, which is a prominent characteristic of the hepatic promoters, the effect of aspirin on hepatic tumorigenesis in the rat has been studied. Male Wistar rats were initiated with a diet containing 0.06% 3'-methyl-4-dimethylamino-azobenzene...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227195
更新日期:1993-07-01 00:00:00